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(Pursuant to reply on 28.07.2000 at 354 c1000W) To ask the Secretary of State for Health, pursuant to his Answer of 28th June 2000 at 352 c511-2W, if he will place in the Library a copy of the outstanding National Poisons Information Service Centre reports for the year 1999-2000 that...

Asked by

Lord Tyler (Liberal Democrat)

Answering body

Department of Health

Type

Written questions

Status

Answered

Date

23 October 2000

Reference

355 c78W; 133299;133288;133300

House

House of Commons

Deposited Paper Dep 00/1466

Deposited by

Department of Health

Type

Deposited papers

Date

10 October 2000

Reference

Dep 00/1466

House

House of Commons

Dept of Health

To ask the Secretary of State for Health, pursuant to his Answer of 28th June 2000 at 352 c511-2W, if he will place in the Library a copy of the outstanding National Poisons Information Service Centre reports for the year 1999-2000 that were scheduled to be completed by the end...

Asked by

Lord Tyler (Liberal Democrat)

Answering body

Department of Health

Type

Written questions

Status

Answered

Date

28 July 2000

Reference

133299;133288;133300; 354 c1000W

House

House of Commons

Dept of Health

To ask the Secretary of State for Health, pursuant to his Answer of 28th June 2000 at 352 c511-2W, on the National Poisons Information Service, if he will list the other associated activities that take place at the Medical Toxicology Unit.

Asked by

Lord Tyler (Liberal Democrat)

Answering body

Department of Health

Type

Written questions

Status

Answered

Date

28 July 2000

Reference

354 c1000-1W; 133297

House

House of Commons

Dept of Health

To ask the Secretary of State for Health, pursuant to his Answer of 28th June, Official Report, columns 511-12W, what (a) staff, (b) staff-time, (c) services and (d) in-laid support are provided to the Medical Toxicology Unit at Guy's and St. Thomas' by the agrochemical industry; and on what basis...

Asked by

Lord Tyler (Liberal Democrat)

Answering body

Department of Health

Type

Written questions

Status

Answered

Date

28 July 2000

Reference

354 c1000W; 133290

House

House of Commons

Dept of Health

To ask the Secretary of State for Health, pursuant to his Answer of 28th June 2000 at 352 c511-2W, on the National Poisons Information Service Board, from what sources the establishment of the equipment and testing procedures at the Medical Toxicology Unit at Guys' and St. Thomas' has been funded.

Asked by

Lord Tyler (Liberal Democrat)

Answering body

Department of Health

Type

Written questions

Status

Answered

Date

28 July 2000

Reference

354 c1001W; 133289

House

House of Commons

Ministry of Defence;Defence Evaluation and Research Agency

To ask the Secretary of State for Defence, pursuant to his Answer of 27th June, Official Report, 352 c434, on Porton Down, if it is the assessment of the Chemical Defence Establishment that the nerve agent GF is more toxic to humans than sarin (GB). - Text of letter from...

Asked by

Lord Taylor of Goss Moor (Liberal Democrat)

Answering body

Ministry of Defence

Type

Written questions

Status

Answered

Date

25 July 2000

Reference

354 c547-8W; 130528

House

House of Commons

Dept of Health

To ask the Secretary of State for Health, since 1990, what work on pesticides has been carried out by the Medical Toxicology Unit (Guy's and St Thomas' Hospital Trust) and the NPIS (London) under contract to agrochemical companies; what equipment, facilities and staff funded by his Department have been used...

Asked by

Lord Tyler (Liberal Democrat)

Answering body

Department of Health

Type

Written questions

Status

Answered

Date

28 June 2000

Reference

127021; 352 c511-2W

House

House of Commons

Ministry of Defence;Defence Evaluation and Research Agency

To ask the Secretary of State for Defence, what assessment the Chemical Defence Establishment at Porton Down has made of the toxicity to humans of (a) the nerve agent GF and (b) sarin GB. - Inc text of letter from John Chisholm of the Defence Evaluation and Research Agency.

Asked by

Lord Taylor of Goss Moor (Liberal Democrat)

Answering body

Ministry of Defence

Type

Written questions

Status

Answered

Tabled on

16 June 2000

For answer on

27 June 2000

Answered on

27 June 2000

Mr. Matthew Taylor: To ask the Secretary of State for Defence what assessment the Chemical Defence Establishment at Porton Down has made of the toxicity to humans of (a) the nerve agent GF and (b) sarin GB. [127132] Dr. Moonie: This is a matter for the Chief Executive of the Defence Evaluation and Research Agency. I have asked the Chief Executive to write to the hon. Member. Letter from John Chisholm to Mr. Matthew Taylor, dated 27 June 2000: I am replying to your parliamentary question about nerve agents and their toxicity to humans since the laboratories at Porton Down are part of the Defence Evaluation and Research Agency (DERA). GB (sarin) and GF (cyclosarin) are organophosphorus nerve agents developed during World War II in Germany. Both agents are highly toxic chemicals. GB is a highly volatile liquid and is a particular hazard following inhalation, GF is some 30-35 times less volatile and presents a particular hazard from absorption through skin. In hot climates, however, GF may also present a significant hazard from inhalation. Both GB and GF are potent inhibitors of the enzyme acetylcholinesterase, which is responsible for the control of the important chemical messenger acetylcholine within the nervous system. When humans are poisoned, the signs and symptoms of acute poisoning progress from a general feeling of malaise, pinpoint pupils (miosis), excessive sweating, salivation, runny nose and breathing difficulties, through nausea, vomiting and muscle tremor, to loss of consciousness, convulsions and death from respiratory failure. The severity of these signs and their rate of progress depends upon the dose and route of exposure to the nerve agents. In general, those agents absorbed through the skin, such as GF, will exhibit a delayed onset of poisoning and those which are inhaled, such as GB, will exhibit a very rapid onset (within 1-2 min) of signs and symptoms of poisoning. A knowledge of the toxicity of these nerve agents has been built up over the years since the Second World War. Assessments have been prompted by intelligence reports of the chemical arsenals of potential aggressors, for example Iraq. They have been based upon studies in animals and to a limited extent in humans conducted within the UK and the Allied Nations. A number of these studies were carried out at Porton Down between 1948 and 1989. The last trial looked at the effects on the eye of low levels of GB. The trial was conducted to assess the effects from "the maximum dosage of nerve agent vapour to the eyes acceptable for aircrew" under NATO prescribed conditions. Scientists at Porton Down have also undertaken three paper exercises to examine the possible long-term effects of nerve agent exposure using the service medical records of volunteers previously exposed to GB. None of the three studies showed any significant difference between the patterns of days lost through illness, the number of specialist appointments or the number of hospital admissions between the control and exposed groups. Medical countermeasures to both GB and GF have been developed at CBD Porton Down and the combination of pre-treatment with Nerve Agent Pre-Treatment Set (NAPS) tablets and use of the ComboPen injector, which contains atropine, an oxime (P2S) and an anticonvulsant (Avizafone), provide effective antidotes against poisoning by these agents. I hope the above is helpful.

Date

27 June 2000

Reference

127132; 352 c434W

House

House of Commons

Home Office

To ask the Secretary of State for the Home Department, what representations have been made to him on reducing the number of dogs used in regulatory toxicology; and if he will make a statement. - Inc figures and ref to Animals (Scientific Procedures) Act 1986.

Asked by

Mike Hancock (Liberal Democrat)

Answering body

Home Office

Type

Written questions

Status

Answered

Date

17 April 2000

Reference

348 c380W; 118901

House

House of Commons

Librarians' tools

Type

House

Session

Month

Department

Member

Primary member

Answering member

Legislative stage

Legislation

Subject

Publisher